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Significant changes are brought in the gut microbiotas composition and functions, leading to microbial dysbiosis, leaky gut, and immune and metabolic dysfunction because of microgravity, radiation, and psychological stress, impacting the astronauts health negatively by making them susceptible to infections, inflammations, and cognitive impairments (Nie et al

This absence of IGF-1 stimulation has been consistently demonstrated across multiple studies and dose ranges

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With diminished sodium-potassium ATPase activity, intracellular sodium levels rise, driving subsequent calcium entry through the sodium-calcium exchanger [17]